Historic Downtown La Crosse, WI Much more than your ordinary, quaint small-town Main Street, historic downtown La Crosse, Wisconsin, has so much to offer: unique shopping opportunities, fine dining, great entertainment venues, and a vibrant nightlife. Spend your day browsing at some of the region’s finest specialty shops, get a bite at any of several fine-dining establishments, and relax beside the Mississippi at Riverside Park. Or just walk around and take in the sites of downtown’s historic architecture. It’s all here waiting for you.